Stick to the recommended oil change interval unless you run a bypass filter system, and back it up with analysis. Synthetic or conventional, without a bypass filter setup, you can't extend the oil interval without running the risk of injector problems. Remember these injectors use high pressure engine oil for fuel injection, so if you run dirty oil, you get injection trouble. Dirty oil will increase the possibility of injector stiction in cold weather. Probably the best single thing you can do to ensure trouble free operation with a 6.0 is regular oil changes. Synthetic, and bypass filtration will only increase your reliability.